The role of fecal calprotectin in investigating inflammatory bowel diseases

AUTOR(ES)

Erbayrak, Mustafa, Turkay, Cansel, Eraslan, Elife, Cetinkaya, Hulya, Kasapoglu, Benan, Bektas, Mehmet

FONTE

Clinics

DATA DE PUBLICAÇÃO

2009-05

RESUMO

INTRODUCTION: Invasive and non-invasive tests can be used to evaluate the activity of inflammatory bowel diseases. OBJECTIVE: The aim of the present study was to investigate the role of fecal calprotectin in evaluating inflammatory bowel disease activity and the correlation of fecal calprotectin with the erythrocyte sedimentation rate and C reactive protein values in inflammatory bowel disease. METHOD: Sixty-five patients affected with inflammatory bowel disease were enrolled. Twenty outpatients diagnosed with inflammatory bowel disease comprised the control group. RESULTS: In the present study, all patients in the control group had an fecal calprotectin value lower than the cut-off point (50 mg/kg). CONCLUSION: In conclusion, fecal calprotectin was found to be strongly associated with colorectal inflammation indicating organic disease. Fecal calprotectin is a simple and non-invasive method for assessing excretion of macrophages into the gut lumen. Fecal calprotectin values can be used to evaluate the response to treatment, to screen asymptomatic patients, and to predict inflammatory bowel disease relapses.

Documentos Relacionados

• Inflammatory Bowel Diseases
• A role for proteinase-activated receptor–1 in inflammatory bowel diseases
• Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
• The role of Escherichia coli in inflammatory bowel disease
• Classical and recent advances in the treatment of inflammatory bowel diseases