The Nature of the Ground States of Cobalt(II) and Nickel(II) Carboxypeptidase A

AUTOR(ES)

Rosenberg, Robert C.

RESUMO

The magnetic susceptibilities of cobalt(II) and nickel(II) derivaties of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 ± 0.15 and 2.53 ± 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.

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