The N-ras oncogene assigned to the short arm of human chromosome 1.
AUTOR(ES)
de Martinville, B
RESUMO
The human N-ras oncogene, isolated from the HL-60 promyelocytic leukemia cell line, is distantly related to viral oncogenes of Kirsten and Harvey sarcoma viruses. We have determined its chromosomal location by Southern blot analysis of DNAs from 37 human x rodent hybrid cell lines derived from 8 different human donors, some of whom carried balanced rearrangements of chromosome 1. The results indicate that the N-ras oncogene (RASN) is localized on the proximal part of the short arm of human chromosome 1, in region p3200 leads to cen.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=326261Documentos Relacionados
- Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation.
- Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors.
- Mutações do oncogene N-ras em leucemias agudas
- Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.
- Activation of N-ras in a human melanoma cell line.
