The meiosis-specific Xmr gene product is homologous to the lymphocyte Xlr protein and is a component of the XY body.
AUTOR(ES)
Calenda, A
RESUMO
The Xlr (X-chromosome linked, lymphocyte regulated) multigene family was previously found to determine, in the lymphoid cell lineage, the stage-specific expression of a nuclear protein with a primary sequence suggestive of a transcriptional activator function. We report here the characterization of a second functional member of the Xlr gene family that is abundantly transcribed in testis in a tissue-specific and developmentally regulated manner. The protein product of this newly identified gene, called Xmr (Xlr-related, meiosis regulated), is located in the nuclei of spermatocytes, early in the prophase of the first meiotic division, and later becomes concentrated in the XY nuclear subregion where it is in particular associated with the axes of sex chromosomes. The Xmr protein provides a new tool for the investigation of sex chromosome behaviour during meiosis in mammals.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=394783Documentos Relacionados
- UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene expression.
- SPO21 Is Required for Meiosis-specific Modification of the Spindle Pole Body in Yeast
- A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination
- Dlh1 Is a Functional Candida Albicans Homologue of the Meiosis-Specific Gene Dmc1
- Isolation, DNA sequence, and regulation of a meiosis-specific eukaryotic recombination gene.
