The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population

AUTOR(ES)

Cimponeriu, Danut, Apostol, Pompilia, Radu, Irina, Craciun, Anne Marie, Serafinceanu, Cristian, Toma, Mihai, Panaite, Cristian, Cheta, Dan

FONTE

Genetics and Molecular Biology

DATA DE PUBLICAÇÃO

08/09/2010

RESUMO

The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.

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