The influence of bisphosphonates on induced tooth movement and root resorption / "Influência dos bisfosfonatos na movimentação dentária induzida, na freqüência e nas dimensões das reabsorções radiculares associadas"

AUTOR(ES)

Maria Fernanda Martins e Ortiz

DATA DE PUBLICAÇÃO

2004

RESUMO

Bisphosphonates are a class of drugs acknowledged for their ability to prevent bone resorption. The presented study tested the following hypothesis: Could bisphosphonates prevent root resorption once incorporated into dentin or cementum? 89 Wistar rats (Rattus norvegicus, albinus) with and without bisphosphonate medication, alendronate, at a dosage of 1mgP/Kg twice-weekly, were submitted to induced tooth movement for 0, 3, 5 and 7 days. The orthodontic appliance consisted of a coil spring moving the fist left molar foreword supported by the incisor. The rats were divided into 4 groups and submitted to different protocols of medication. The Control Group received no medication whatsoever; Experimental Group 1 was submitted to alendronate intake since intrauterine life until the end of the experiment; Experimental Group 2 received alendronate during intrauterine life until the 60th day of life. A month after medication interruption the molars were moved prior to rats sacrifice. Experimental Group 3, consisted of a group of adult rats alendronate treated after the third month of life until the seventh, when dental movement took place. Microscopic and statistical analysis revealed that animals submitted to alendronate therapy presented significantly reduced amounts of root resorption. There was no further influence of alendronato on bone structure during induced tooth movement. These results allow us to conclude that the use of bisphosphonates, alendronate, to be more specific, may increase the resistance to root resorption during induced tooth movement or even due to traumatisms.

ASSUNTO(S)

cemento dentário patologia bucal dentina

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