The Glycoprotein D (US6) Homolog Is Not Essential for Oncogenicity or Horizontal Transmission of Marek’s Disease Virus†

AUTOR(ES)

Anderson, Amy S.

FONTE

American Society for Microbiology

RESUMO

RB1BUS6lacgpt, a Marek’s disease virus (MDV) mutant having a disrupted glycoprotein D (gD) homolog gene, established infection and induced tumors in chickens exposed to it by inoculation or by contact. Lymphoblastoid cell lines derived from RB1BUS6lacgpt-induced tumors harbored only the mutant virus. These results provide strong evidence that an intact gD homolog gene is not essential for oncogenicity or horizontal transmission of MDV.

Documentos Relacionados

• Protection against Marek's disease by a fowlpox virus recombinant expressing the glycoprotein B of Marek's disease virus.
• Induction of Deoxyribonucleic Acid Synthesis and the Oncogenicity of Marek's Disease Virus
• Oncogenicity of Virulent Marek's Disease Virus Cloned as Bacterial Artificial Chromosomes
• Recombinant fowlpox viruses expressing the glycoprotein B homolog and the pp38 gene of Marek's disease virus.
• The Marek’s disease virus (MDV) protein encoded by the UL17 ortholog is essential for virus growth