The effect of vasopressin on renal tubular 22Na efflux in the rat.

AUTOR(ES)

Fejes-Tóth, G

RESUMO

1. Paired tracer microinjections of [3H]inulin and 22Na were performed at late proximal and early distal puncture sites in water diuresis and during vasopressin-induced antidiuresis in anaesthetized rats. Vasopressin caused a sixfold increase in Na and a fourfold increase in K excretion without significant changes in renal haemodynamics. 2. 22Na-recovery from late proximal injections increased nearly fivefold (from 0.98+/- 0.16 to 4.76 +/- 0.66%, P less than 0.001). A significant correlation could be detected between changes in sodium excretion and changes in late proximal 22Na recovery. Vasopressin had no significant effect on 22Na recovery from early distal injections. 3. These results suggest that vasopressin inhibits active salt reabsorption within the loop of Henle.

Documentos Relacionados

• The effect of vasopressin on renal blood flow and its distribution in the rat.
• Effect of arginine vasopressin on renal medullary blood flow. A videomicroscopic study in the rat.
• Dinitrophenol effect on proximal tubular acidification in the rat.
• Effect of acute hypercapnia on renal and proximal tubular total carbon dioxide reabsorption in the acetazolamide-treated rat.
• Dose-response effects of pressor doses of arginine vasopressin on renal haemodynamics in the rat.