The effect of the therapeutical ultrasound in the treatment of the injuries for crushing of the ciático nerve of rats / Os efeitos do ultra-som terapêutico no tratamento das lesões por esmagamento do nervo ciático de ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

An experimental study of the influence of therapeutic ultrasound on the regeneration of the sciatic nerve submitted to controlled crush injury was carried out in rats. Twenty female Wistar rats weighing 250 g on average were used and distributed in two groups according to the procedure: 1) crush injury only, ten rats; 2) crush injury followed by ultrasound irradiation, ten rats. Under general anesthesia the sciatic nerve was exposed on the right thigh and crushed with a device especially devised and built for that purpose, with a 15 kg constant load for 10 minutes, affecting a 5 mm-long segment of the nerve proximal to its bifurcation. Pulsed ultrasound irradiation (1:5, 1 MHz frequency, 0.4 W/ CM POT.2 intensity, 2 minutes duration) was started the day after the operation and repeated for ten consecutive days. The results were evaluated by functional footprint analysis and determination of the sciatic functional index (DeMedinaceli s and Bain, Mackinnon and Hunter s methods) at weekly intervals, and by morphometry (nerve fiber density) of the resected sciatic nerve after killing the animals on the 21st postoperative day. Results were submitted to statistical evaluation and showed that, in the conditions of the study, ultrasound accelerated nerve regeneration, as demonstrated with significance on the 21st postoperative day

ASSUNTO(S)

regeneração de nervo periférico índice funcional do ciático sciatic nerve of rats therapeutic ultrasound sciatic functional index nervo ciático de ratos peripheral nerve regeneration nerve fiber density crush injury lesão por esmagamento ultra-som terapêutico densidade de fibras nervosas

ACESSO AO ARTIGO

Documentos Relacionados