The effect of phosphoethanolamine intake on mortality and macrophage activity in mice with solid ehrlich tumors

AUTOR(ES)

Arruda, Maria Sueli Parreira de, Correa, Mara Adriana, Venturini, James, Félix, Maira Camila, Rosis, Ana Maria Bormio De, Galhiane, Mário Sérgio, Chierice, Gilberto Orivaldo, Costa, Maria Renata Sales Nogueira

FONTE

Brazilian Archives of Biology and Technology

DATA DE PUBLICAÇÃO

2011-12

RESUMO

The aim of the present study was to examine the effect of a diet rich in synthetic PEtn on the metabolism macrophages of tumor-bearing mice. The results demonstrated that PEtn increased the animals' survival time. In addition, the treated animals released smaller amounts of hydrogen peroxide (H2O2) and nitric oxide (NO) than the non-treated animals, particularly after day 14. From the results it could be concluded that H2O2 and NO were important in the modulation of neoplastic growth, and pointed to a promising role of PEtn in the control of human neoplasms.

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