The Effect of an Intronic Polymorphism on Alcohol Dehydrogenase Expression in Drosophila Melanogaster
AUTOR(ES)
Laurie, C. C.
RESUMO
Several lines of evidence indicate that natural selection controls the frequencies of an allozyme polymorphism at the alcohol dehydrogenase (Adh) locus in Drosophila melanogaster. However, because of associations among sequence polymorphisms in the Adh region, it is not clear whether selection acts directly (or solely) on the allozymic site. This problem has been approached by using in vitro mutagenesis to distinguish among the effects on Adh expression of individual polymorphisms. This study shows that a polymorphism within the first Adh intron ( &1) has a significant effect on the level of ADH protein. Like the allozyme, & shows a geographic cline in frequency, indicating that it may also be a target of natural selection. These results suggest that multisite selection models may be required to understand the evolutionary dynamics of individual loci.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1206156Documentos Relacionados
- Measuring Selection Coefficients Affecting the Alcohol Dehydrogenase Polymorphism in DROSOPHILA MELANOGASTER
- The Alcohol Dehydrogenase Polymorphism in Populations of DROSOPHILA MELANOGASTER. I. Selection in Different Environments
- Effects of a Transposable Element Insertion on Alcohol Dehydrogenase Expression in Drosophila Melanogaster
- Molecular Dissection of a Major Gene Effect on a Quantitative Trait: The Level of Alcohol Dehydrogenase Expression in Drosophila Melanogaster
- The Alcohol Dehydrogenase Polymorphism in Drosophila Melanogaster: Fitness Measurements and Predictions under Conditions with No Alcohol Stress
