The Chemotherapy of Poisoning by Organophosphate Anticholinesterases
AUTOR(ES)
Davies, D. R.
RESUMO
Oximes (with or without atropine as an adjunct) have recently been used successfully in the treatment of humans poisoned by organophosphate anticholinesterases. The discovery of the nature of the biochemical lesion in organophosphate poisoning has permitted the design of drugs to repair specifically this particular lesion. This paper reviews historically the researches which led to the development of pyridine-2-aldoxime methiodide (PAM) and its corresponding methanesulphonate (P2S), the two most successful oximes yet tried, and summarizes the theoretical background to their rational use.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1037905Documentos Relacionados
- Intensive care management of organophosphate insecticide poisoning
- Electrophysiological studies in acute organophosphate poisoning.
- Pathophysiological studies of neuromuscular function in subacute organophosphate poisoning induced by phosmet.
- Cardiac manifestations of acute carbamate and organophosphate poisoning.
- Subacute poisoning with phosalone, an organophosphate insecticide.
