The c-myc Locus Is a Common Integration Site in Type B Retrovirus-Induced T-Cell Lymphomas

AUTOR(ES)

Rajan, Lakshmi

FONTE

American Society for Microbiology

RESUMO

Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance.

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