The antibody catalysis route to the total synthesis of epothilones
AUTOR(ES)
Sinha, Subhash C.
FONTE
The National Academy of Sciences
RESUMO
An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using antibody-catalyzed aldol and retro-aldol reactions. These precursors were then converted to epothilones A (1) and C (3) to complete the total synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=24496Documentos Relacionados
- Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine
- Catalysis of a stereospecific bimolecular amide synthesis by an antibody.
- Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
- Organometallic catalysis: some contributions to organic synthesis
- An approach to the total synthesis of sinefungin.
