Ternary phase diagram of ketamine ((R,S)-2-(2-chlorophenyl)-2methylaminocyclohexanone) in ethanol and preliminary studies aiming at Enantioselective Crystallization of S-ketamine
AUTOR(ES)
Barros, G. O. F., Tamagawa, R. E., Santana, C. C., Miranda, E. A.
FONTE
Brazilian Journal of Chemical Engineering
DATA DE PUBLICAÇÃO
2009-06
RESUMO
Crystallization is an important industrial-scale process for the purification of enantiomers that depends on a phase diagram. In this work, the ternary phase diagram of R- and S-ketamine in ethanol was determined. The eutectic point indicated that crystallization of pure enantiomers from solutions containing more than 75% of the desired enantiomer is feasible. Solubility studies showed the feasibility of using temperature control to conduct the process. Batch crystallization of ketamine (S/R:80/20) solutions at 25ºC provided the isolation of S-ketamine (purity of 100%) with a yield from 65 to 70% and a productivity of 6.5 g/(lh).
Documentos Relacionados
- Purification, crystallization and preliminary crystallographic studies of SPCI–chymotrypsin complex at 2.8 Å resolution
- Enantioselective resolution of (R,S)-1-phenylethanol catalyzed by lipases immobilized in starch films
- Purification, crystallization and preliminary crystallographic studies of plant S-adenosyl-l-homocysteine hydrolase (Lupinus luteus)
- PROINSULIN: CRYSTALLIZATION AND PRELIMINARY X-RAY DIFFRACTION STUDIES*
- Phase diagram of cuprate superconductors at ultrahigh magnetic fields