T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children

AUTOR(ES)

Trujillo-Ochoa, Jorge L, Corral-Jara, Karla F, Escobedo-Meléndez, Griselda, Realpe, Mauricio, Panduro, Arturo, Roman, Sonia, Fierro, Nora A

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

31/03/2015

RESUMO

We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediate liver injury compared with those with minor liver damage was found. A reduction in the IgE levels in those patients who showed the highest levels of IL-17F in the group of intermediate liver injury was found. The data suggested that the Th17-related profile is associated with the severity of HAV infection and might play a role on the modulation achieved by HAV during allergies.

Documentos Relacionados

• Induction of rabies virus-specific T-helper cells by synthetic peptides that carry dominant T-helper cell epitopes of the viral ribonucleoprotein.
• Production of T-helper cell subsets and cytokines by lymphocytes from patients with chronic mucocutaneous candidiasis.
• Control of Heterologous Hepatitis C Virus Infection in Chimpanzees Is Associated with the Quality of Vaccine-Induced Peripheral T-Helper Immune Response
• Human Immunodeficiency Virus Type 1 Evades T-Helper Responses by Exploiting Antibodies That Suppress Antigen Processing
• Early Induction and Maintenance of Env-Specific T-Helper Cells following Human Immunodeficiency Virus Type 1 Infection