Systemic lupus erythematosus and Raynaud's phenomenon
AUTOR(ES)
Heimovski, Flavia Emilie, Simioni, Juliana A., Skare, Thelma Larocca
FONTE
An. Bras. Dermatol.
DATA DE PUBLICAÇÃO
2015-12
RESUMO
Abstract: BACKGROUND: Patients with systemic lupus erythematosus seem to belong to different serological and clinical subgroups of the disease. Genetic background can cause the appearance of these subgroups. OBJECTIVE: To determine whether Brazilian patients who have systemic lupus erythematosus and Raynaud's phenomenon differ from those who do not. METHODS: Retrospective analysis of 373 medical records of systemic lupus erythematosus patients studied for demographic, clinical and serological data. A comparative analysis was performed of individuals with and without RP. RESULTS: There was a positive association between Raynaud's phenomenon and age at diagnosis (p=0.02), presence of anti-Sm (p=0.01) antibodies and anti-RNP (p<0.0001). Furthermore, a negative association was found between Raynaud's phenomenon and hemolysis (p=0.01), serositis (p=0.01), glomerulonephritis (p=0.0004) and IgM aCL (p=0.004) antibodies. CONCLUSION: Raynaud's phenomenon patients appear to belong to a systemic lupus erythematosus subset with a spectrum of clinical manifestations located in a more benign pole of the disease.
Documentos Relacionados
- Measurement of cold challenge responses in primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis.
- Raynaud's phenomenon
- Raynaud's Phenomenon*
- A controlled study of stanozolol in primary Raynaud's phenomenon and systemic sclerosis.
- Bosentan therapy for patients with severe Raynaud's phenomenon in systemic sclerosis