Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.
AUTOR(ES)
Zhou, L
RESUMO
We describe the synthesis and characterization of novel phosphorothioate-methylphosphonate backbone-modified oligodeoxynucleotide co-polymers. These may have potential use as antisense constructs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=523603Documentos Relacionados
- Branched co-polymers of histidine and lysine are efficient carriers of plasmids
- Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages.
- A new approach to the synthesis of the 5'-deoxy-5'-methylphosphonate linked thymidine oligonucleotide analogues.
- Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers.
- Kinetics of phosphorothioate oligonucleotide metabolism in biological fluids.