Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
AUTOR(ES)
Amaral, Patricia de A., Petrignet, Julien, Gouault, Nicolas, Agustini, Taciane, Lohézic-Ledévéhat, Françoise, Cariou, Alexandre, Grée, René, Eifler-Lima, Vera L., David, Michèle
FONTE
Journal of the Brazilian Chemical Society
DATA DE PUBLICAÇÃO
2009
RESUMO
Reações de acoplamento do tipo Heck, Sonogashira-Hagihara, Suzuki-Miyaura e reação de aldolisação catalizadas por metal foram utilizadas para a obtenção de três séries de δ-valerolactonas substituídas em posições 3, 4, 5 e 6 do anel lactônico. As 26 δ-valerolactonas sintetizadas foram testadas contra três linhagens celulares e cinco delas exibiram uma moderada atividade citotóxica.
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