Synthesis of Biphenyl Tyrosine Via Cross-Coupling Suzuki-Miyaura Reaction Using Aryltrifluoroborate Salts

AUTOR(ES)

Vasconcelos, Stanley N. S., Barbeiro, Cristiane S., Khan, Amna N., Stefani, Hélio A.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

We reported a fast and easy method for obtaining biarylic units from tyrosine derivatives via Suzuki-Miyaura cross-coupling using a variety of substituted and unsubstituted potassium aryl- and heteroaryltrifluoroborate salts. The scope of the methodology was also extended to the formation of bis-tyrosine linked dipeptide bonds, leading to biologically interesting compounds. Some biarylic units were obtained as free amino acids through the one step cleavage reaction in good yields.

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