Synthesis of a Homologous Series of Trialkyl Arsines (C3-C12) and Applications of Arsenic Triiodide as a Synthetic Precursor

AUTOR(ES)

Ligiéro, Carolina B. P.; Francisco, Marcos A. S.; Gama, Michelle S.; Carbonezi, Carlos A.; Leocadio, Isabela C. L.; Souza, Wladmir F. de; Esteves, Pierre M.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2021-04

RESUMO

This work presents some modifications in the post-synthetic processing for a classical arsenic reagent: AsI3. In comparison with the widely used analog, the trichloride, arsenic triiodide presents several advantages such as low toxicity, air stability, and low volatility. It was used as a synthetic precursor in the preparation of a variety of arsenic(III) derivatives like arsines, arsenites, and thioarsenites. Besides that, AsI3 was submitted to a diversity-oriented Grignard reaction in the preparation of a homologous series of trialkyl arsines ranging from AsC3H9 to AsC12H27. The series was analyzed by comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry to provide a trialkyl arsines library that can be used for the direct analysis of natural samples.

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