Synthesis and characterization of triblock anfiphilic biodegradable copolymer poly(l,l-lactide-stat-e-caprolactone)-b-poly(ethylene oxide)-b-poly(l,l-lactide-stat-e-caprolactone). / Síntese e caracterização do copolímero tribloco anfifílico biodegradável poli(L, L-lactídeo-stat-e-caprolactona)-bloco-poli(óxido de etileno)-bloco-poli(L, L-lactídeo-stat-e-caprolactona).

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

This work includes the study of the synthesis and characterization of the copolymer poly(l,l-lactide-stat-e-caprolactone)-b-PEG-b-poly(l,l-lactide-stat-e-caprolactone). Poly (ethylene oxide) with molar weight 20.000 and poly(ethylene oxide) modified, prepared from poly(ethylene oxide) with molar weight 4000 have been selected for this synthesis process. The reaction was done by ring-opening bulk polymerization, using stannous octoate as initiator at 120ºC. The chemical composition of samples were determined by 1H-NMR and 13C-NMR and their mechanical properties were verified using thermal analyses like DMTA, DSC and TG. Scanning electron microscopy (SEM) was applied as a complementary analysis. The pictures of polarizing optical microscopy showed us the copolymers nucleation behaviors and their respective crystallization. The degrees of crystallinity and phase of copolymers were determined by WAXS. The biocompatibility of the copolymer was examined by cell cultivation test. The result of these analyses above indicated the success of synthesis. Their rubbery properties and non-toxicity allowed their application as biomaterial. However, the long reaction time and low incorporation of monomer of lactide might to be improved to increase its potential use in biomedical area in the future.

ASSUNTO(S)

poly(ethylene oxide) biodegradable copolymer triblock copolymer poli(ll-lactídeo-stat-e-caprolactona) copolímero tribloco poli(óxido de etileno) copolímero biodegradável poly(ll-lactide-stat-e-caprolactone)

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