Synthesis and Biological Evaluation of Novel Betulin Derivatives with Aromatic Hydrazone Side Chain as Potential Anticancer Agents
AUTOR(ES)
Wang, Jiafeng; Wu, Jiale; Han, Yinglong; Zhang, Jie; Lin, Yu; Wang, Haijun; Wang, Jing; Bu, Ming
FONTE
Journal of the Brazilian Chemical Society
DATA DE PUBLICAÇÃO
2022
RESUMO
A series of novel betulin-28-hydrazone derivatives (7a-7o) were synthesized. All compounds were evaluated for their in vitro cytotoxicities in four human carcinoma cells (HepG2, MCF-7, HCT-116 and A549). Among them, compound 7l displayed the most potent cytotoxicity with an IC50 (concentration of the tested compound that inhibits 50% of cell growth) value of 7.37 ± 0.38 μM against MCF-7 cells. The preliminary cellular mechanism studies indicated that compound 7l could induce MCF-7 cells apoptosis. The above findings indicated that compound 7l may be used as a lead compound for antitumor agents with improved efficacy.
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