Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages.

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RESUMO

The combination of clarithromycin and pyrazinamide was found to be synergistic against Mycobacterium tuberculosis in human macrophages. MICs were four- to eightfold lower for this combination than they were for either drug alone. Clarithromycin and rifampin, however, had only an additive effect.

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