Symmetry and the energy landscapes of biomolecules

AUTOR(ES)

Wolynes, Peter G.

FONTE

The National Academy of Sciences of the USA

RESUMO

The role of symmetry in the folding of proteins is discussed using energy landscape theory. An analytical argument shows it is much easier to find sequences with funneled energy landscape capable of fast folding if the structure is symmetric. The analogy with phase transitions of small clusters with magic numbers is discussed.

Documentos Relacionados

• Symmetry and frustration in protein energy landscapes: A near degeneracy resolves the Rop dimer-folding mystery
• RNA folding energy landscapes
• Solvent effects on the energy landscapes and folding kinetics of polyalanine
• Geometry and symmetry presculpt the free-energy landscape of proteins
• Folding funnels and energy landscapes of larger proteins within the capillarity approximation