"Sweet Chemistry": a Green Way for Obtaining Selenium Nanoparticles Active against Cancer Cells
AUTOR(ES)
Vieira, Adriana P., Stein, Erika M., Andreguetti, Daniel X., Cebrián-Torrejón, Gerardo, Doménech-Carbó, Antonio, Colepicolo, Pio, Ferreira, Ana Maria D. C.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2017-10
RESUMO
We present an environment friendly synthesis of selenium nanoparticles and the study of their cytotoxic activity against uterine sarcoma cancer and fibroblasts cells. Amorphous selenium (a-SeNPs) and trigonal selenium (t-SeNPs) were synthesized using D-fructose as the reducing agent and characterized by high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction analysis (XRD), inductively coupled plasma optical emission spectrometry (ICP OES), dynamic light scattering (DLS) to obtain zeta potential values and cyclic voltammetry (CV). Particularly, a-SeNPs presented high toxicity toward the resistant cancer cell line MES-SA/Dx5 and its parental MES-SA line. However, they are not toxic against P4 fibroblast cells in comparative studies.
