SURVEY AND SUMMARY: Structural classification of zinc fingers
AUTOR(ES)
Krishna, S. Sri
FONTE
Oxford University Press
RESUMO
Zinc fingers are small protein domains in which zinc plays a structural role contributing to the stability of the domain. Zinc fingers are structurally diverse and are present among proteins that perform a broad range of functions in various cellular processes, such as replication and repair, transcription and translation, metabolism and signaling, cell proliferation and apoptosis. Zinc fingers typically function as interaction modules and bind to a wide variety of compounds, such as nucleic acids, proteins and small molecules. Here we present a comprehensive classification of zinc finger spatial structures. We find that each available zinc finger structure can be placed into one of eight fold groups that we define based on the structural properties in the vicinity of the zinc-binding site. Three of these fold groups comprise the majority of zinc fingers, namely, C2H2-like finger, treble clef finger and the zinc ribbon. Evolutionary relatedness of proteins within fold groups is not implied, but each group is divided into families of potential homologs. We compare our classification to existing groupings of zinc fingers and find that we define more encompassing fold groups, which bring together proteins whose similarities have previously remained unappreciated. We analyze functional properties of different zinc fingers and overlay them onto our classification. The classification helps in understanding the relationship between the structure, function and evolutionary history of these domains. The results are available as an online database of zinc finger structures.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=140525Documentos Relacionados
- SURVEY AND SUMMARY: The pre-ribosomal network
- SURVEY AND SUMMARY: The phylogenetic distribution of bacterial ribonucleases
- SURVEY AND SUMMARY: Unusual DNA duplex and hairpin motifs
- SURVEY AND SUMMARY: Comparative analysis of editosome proteins in trypanosomatids
- SURVEY AND SUMMARY: The applications of universal DNA base analogues