Suppression of tuberculoimmunity in mice by Evans blue dye.
AUTOR(ES)
Crowle, A J
RESUMO
Evans blue dye, which acts as an adjuvant in mice to promote induction of cell-mediated immunity, was found earlier to apparently act contrarily and decrease tuberculoimmunity. This phenomenon was investigated here in a long-term experiment examining the persistence of the suppressed immunity. Systemic suppression after injection of only 1 mg of dye was confirmed and was found to last for more than 2 weeks but less than 11 weeks. Localized evidence for dye-caused depression of tuberculoimmunity also was seen by the development in dye-injected mice immunized with emulsified whole bacilli of caseating tubercles at sites of pulmonary infection, a very rare type of pathology for tuberculosis in mice. The experiment, in addition, detected an aging-related decline in mice of resistance to tuberculosis evident by shortened survival, enlarged pulmonary tubercles, and increased susceptibility to systemic tuberculin reaction.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347839Documentos Relacionados
- Evans blue dye adjuvant enhances delayed hypersensitivity while blocking immunity to Mycobacterium tuberculosis in mice.
- Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo
- Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye.
- Differential spore and lipid staining at room temperature by use of fluorescent dye.
- BLOOD VOLUME STUDIES IN SHOCK RESULTING FROM MYOCARDIAL INFARCTION. I. STUDIES WITH EVANS BLUE DYE (T-1824) 1
