Superoxide dismutase in Cryptococcus neoformans varieties gattii, grubi, and neoformans

AUTOR(ES)

Dias, ALT, Brigagão, MRPL, Colepicolo, P, Siqueira, AM, Silva, EG da, Paula, CR

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2006-02

RESUMO

Some clear dissimilarities occur among the varieties of Cryptococcus neoformans but there are few studies about the differences among individual yeast antioxidant enzymes. The total superoxide dismutase (SOD) activities and the copper, zinc-depend SOD (Cu,ZnSOD) and manganese-dependent SOD (MnSOD) isoenzymes of five reference C. neoformans strains belonged to A, B, C, AD and D serotypes (Table I) and other nine C. neoformans isolates (Table II) were determined. There were significant differences (p < 0.01 and p < 0.05) in total SOD activity among the varietie gattii (serotype C) and the other varieties. Cu,ZnSOD showed difference (p < 0.05) between A and D serotypes. These results point out a variety and serotype-independent SOD activity in C. neoformans reference strains and the other isolates that were evaluated.

Documentos Relacionados

• Biochemical comparison of the Cu,Zn superoxide dismutases of Cryptococcus neoformans var. neoformans and Cryptococcus neoformans var. gattii.
• Cryptococcus neoformans var. gattii in Australia.
• Superoxide Dismutase Influences the Virulence of Cryptococcus neoformans by Affecting Growth within Macrophages
• Cryptococcus neoformans Mitochondrial Superoxide Dismutase: an Essential Link between Antioxidant Function and High-Temperature Growth
• Natural habitat of Cryptococcus neoformans var. gattii.