Superinduction of the human interferon-beta promoter.
AUTOR(ES)
Dinter, H
RESUMO
Superinduction, that is induction with simultaneous blocking of mRNA translation, enhances the induction of interferon-beta in response to virus or double-stranded RNA in human fibroblasts. Expression of the cloned IFN-beta gene upon transfer into heterologous cells reflects the endogeneous interferon expression with respect to induction or superinduction indicating the involvement of cellular mediators in this mode of gene regulation. Expression from gene hybrids in mouse Mo57/2 cells reveals that 5' flanking DNA sequences from the human IFN-beta gene are responsible for induction and superinduction. Superinduction of the human IFN-beta promoter is demonstrated in several rodent and primate cell lines. In addition, expression from promoter mutants in mouse cells indicates that DNA sequences responsible for induction and superinduction are identical.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=553439Documentos Relacionados
- Nucleotide sequence of the mouse interferon-beta gene.
- Isolation of novel human genomic DNA clones related to human interferon-beta 1 cDNA.
- Male sterility of transgenic mice carrying exogenous mouse interferon-beta gene under the control of the metallothionein enhancer-promoter.
- Murine interferon-beta receptor-mediated endocytosis and nuclear membrane binding.
- Randomised double-blind trial of recombinant interferon-beta for condyloma acuminatum.