Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.
AUTOR(ES)
Wise, E M
RESUMO
Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide-resistant dihydropteroate synthase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase, EC 2.5.1.15) in addition to the normal sensitive enzyme. The resistant dihydropteroate synthases examined are determined by an R plasmid and are smaller and less heat stable than the normal sulfonamide-sensitive enzyme. One synthase resistant to any sulfonamide tested, and to sulfanilic and arsanilic acids, was still inhibited by several non-sulfonamide analogs of p-aminobenzoate. Citrobacter and Klebsiella pneumoniae strains also show similar mechanisms of sulfonamide resistance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432821Documentos Relacionados
- SULFONAMIDE-RESISTANT STAPHYLOCOCCI: CORRELATION OF IN VITRO SULFONAMIDE—RESISTANCE WITH SULFONAMIDE THERAPY 1
- Biologic Changes in Sulfonamide-resistant Mycobacterium ranae
- THE MORPHOLOGICAL CHARACTERISTICS OF PAIRED SULFONAMIDE-SUSCEPTIBLE AND SULFONAMIDE-RESISTANT STRAINS OF STAPHYLOCOCCUS AUREUS1
- SULFONAMIDE-FAST PNEUMOCOCCI. A CLINICAL REPORT OF TWO CASES OF PNEUMONIA TOGETHER WITH EXPERIMENTAL STUDIES ON THE EFFECTIVENESS OF PENICILLIN AND TYROTHRICIN AGAINST SULFONAMIDE-RESISTANT STRAINS
- Chelocardin-Inducible Resistance in Escherichia coli Bearing R Plasmids