Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
AUTOR(ES)
Marques, Cybelle Teixeira, Azevedo, Tarciana C. G. de, Nascimento, Marília S., Medeiros, Valquíria P., Alves, Luciana G., Benevides, Norma M. B., Rocha, Hugo A. O., Leite, Edda Lisboa
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
21/11/2011
RESUMO
Sulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and ¹H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed. This polysaccharide showed that an MW of 25,000 Da was effective in reducing leukocyte influx into the peritoneal cavity in mice at 10 mg/kg and 25 mg/kg body weight, causing a decrease of 60 and 39%, respectively. In the present study, it was observed that this fucan has anti-inflammatory properties but no cytotoxic action, indicating its potential use in the pharmaceutical industry.
