Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review
AUTOR(ES)
Shen, Tian, Wu, Lihua, Geng, Lei, Wei, Zeqing, Zheng, Shusen
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2011-10
RESUMO
Nocardia infection is rare but potentially fatal. Therapy of Nocardia infection remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, but clinical data are limited. Here we describe a case of a 45-year-old man with pulmonary N. farcinica infection following a liver transplantation. The initial therapy was trimethoprim-sulfamethoxazole, which showed no effect. According to susceptibility test, linezolid was administered with clearly improving the patient's condition. The treatment was stopped for anemia as drug related adverse event, and the therapy lasted for as long as 5 months. At the end of treatment clinical cure was confirmed and anemia reversed after discontinuation of linezolid. We also analyzed the clinical data of previously published reports by literature review, focusing on the efficacy and safety of linezolid treatment for Nocardia infection.
Documentos Relacionados
- Fatal Pulmonary Nocardia farcinica Infection
- Primary pulmonary paraganglioma: case report and literature review
- Primary sternal osteomyelitis caused by Nocardia nova: case report and literature review
- Pure red cell aplasia associated with type I autoimmune polyglandular syndrome—successful response to treatment with mycophenolate mofetil: case report and review of literature
- Treatment of acute hepatitis C virus infection with interferon-α 2b and ribavirin: Case report and review of the literature