Successful Boosting of a DNA Measles Immunization with an Oral Plant-Derived Measles Virus Vaccine

AUTOR(ES)

Webster, Diane E.

FONTE

American Society for Microbiology

RESUMO

Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.

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