Study of vascular permeability and extracellular volume fraction in the differentiation of benign and malignant breast lesions / Estudo da permeabilidade vascular e volume extra-celular na diferenciação das lesões nodulares benignas e malignas da mama

AUTOR(ES)

Erica Elisangela Françolin

DATA DE PUBLICAÇÃO

2009

RESUMO

INTRODUCTION: There has been a great development in the study of breast lesions with the use of contrast-enhanced magnetic resonance. However, several findings are common in malignant and in benign lesions turning their differentiation difficult. The objective of this research was to study the vascular permeability and the extracellular volume fraction (EVF) to verify if these characteristics increase the differentiation between benign and malignant lesions. The Full Time Point application that converts contrast dynamic sequence in color hue maps to calculate permeability and EVF was used for this purpose. METHODS: 31 patients were included in this study with 57 lesions, 29 malignant and 28 benign. All patients signed an informed consent form. First the lesions were classified by the reader radiologist by dynamic analysis according to BI-RADS® classification. Later, the same lesions were selected with the FTP program that calculated vascular permeability and EVF. RESULTS: Results showed that permeability was different for malignant and benign lesions, mean 1.209(±0.424) for malignant and 0.394 (±0.210) for benign. The EVF did not show statistically significant difference between benign and malignant lesions, mean 0.666 (±0.123) for malignant and 0.708 (±0.151) for benign. When compared to BI-RADS® classification, it was observed that lesions had different permeability in different classifications: 0,39 (±0.22) for BI-RADS® 3, 0.56 (±0.39) for BIRADS ® 4 and 1.29 (±0.37) for BI-RADS® 5. This showed that higher malignity lesions had higher permeability. EVF was not different in the different BI-RADS® classifications. CONCLUSION: It can be concluded that vascular permeabilitiy can be a good discriminant in differentiating breast malignant and benign lesions. However the same was not true for EVF.

ASSUNTO(S)

pathological neovascularization vascular permeability mama neovascularização patológica breast cancer breast permeabilidade vascular magnetic resonance imagem por ressonância magnética neoplasia de mama

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