Study of the effect of ozone dissolved in water in the bone repair by immunohistochemical evaluation / Estudo do efeito do ozônio diluído em água na reparação óssea através de avaliação imunoistoquímica

AUTOR(ES)

Juliana Noguti

DATA DE PUBLICAÇÃO

2010

RESUMO

The ozone therapy can be used as an alternative for the treatment of numerous diseases. The goal is to positively affect tissue repair and antisepsis as ozone is a potent antimicrobial agent and has the ability to stimulate blood circulation and immunomodulatory response. These characteristics justify the interest of its application in Medicine and Dentistry. When in contact with body fluids, ozone acts as an oxidant generating reactive oxygen molecules and oxidative products of lipids influencing biochemical events of cellular metabolism. Therefore, the purpose of this study was to evaluate, in an animal model, the effect of ozone application during the bone wound healing process. These analyses were performed by the study of bone cells morphology and immunohistochemical expression of bone matrix proteins. Our results showed that the use of ozone diluted in water for irrigation caused a delay in early stages of bone repair. This delay was more prominent in the first phase of the bone wound healing.

ASSUNTO(S)

ozone reparação óssea ozônio proteínas da matriz óssea bone repair bone matrix proteins

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