Study of purinergic receptors in glial cells from dorsal root ganglia. / Estudo dos receptores purinérgicos em células gliais do glânglio da raiz dorsal.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Purinergic receptors are expressed and play role in the sinalization between neurons and glia. In dorsal root ganglia the soma of the sensory neurons is surrounded by a layer of satellite glial cells, whose function is unclear. There are evidences that ATP is released by neurons to act on receptors in satellite cells. So far, the nature of the purinergic receptors of satellite cells was not fully investigated. This study shows the presence of metabotropics purinergic receptors P2Y1, P2Y2 and/or P2Y4, e P2Y6 in satellite cells from dorsal root ganglia of newborn rats. The demonstration was carried on following the transient increases in intracellular calcium concentration induced by a purinergic agonist. As time goes by, in the presence of fetal bovine serum, there is a remarkable proliferation of glial cells, with predominant fusiform shapes. The fusiform cells also express P2Y1, P2Y2 and/or P2Y4, e P2Y6 receptors. These informations add on the understanding of the complex phenomena of neuron-glia interaction.

ASSUNTO(S)

calcium sensory ganglia cálcio glia receptores purinérgicos células satélites purinergic receptors gânglio sensorial glia sattellites cells

ACESSO AO ARTIGO

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