STUDY OF IMPORTANT PARAMETERS ON THE IRRADIATION OF 124Xe, TO IMPROVE THE PRODUCTION OF 123I WITH HIGH PURITY USING THE CYCLONE-30 CYCLOTRON AT IPEN-CNEN/SP / Estudo de parâmetros relevantes na irradiação de 124-Xe, visando a otimização na obtenção de 123-I ultra puro no Ciclotron Cyclone-30 do IPEN-CNEN/SP

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

The development of diagnosis equipment and therapy procedures in nuclear medicine depends on the availability of commercial radioisotopes. IPEN is the most important institution that provides radioisotopes for national market. In order to achieve this function, IPEN had invested in the acquisition of a 30 MeV Cyclone-30 cyclotron to produce mainly 18F, 67Ga, 201Tl and 123I. The 123I production is the aim of the present work. With the 123I routine production data obtained by proton irradiation of Xe targets with an enrichment greater than 99.8%, it was possible to identify the important parameters that have direct influence on the production yield of high purity degree 123I. Even though the methodology for the commercial production of 123I, there are an scarcity of operational parameters data for this task. In this work the evaluated parameters were: 124Xe pressure, proton beam quality, irradiation time, operational temperature of the irradiation system under irradiation, waiting time to obtain 123I, temperature of washing solution and the impact of the internal Ni coating in the target. With the obtained results it was possible to modify the operational conditions for routine production and increasing the efficiency in about 30%.

ASSUNTO(S)

123i radioisótopo de ciclotron radioisotopo of cyclotron iodo ultra puro i-123 xe-124 production of 123i 124xe pure extreme iodine produção de i-123

ACESSO AO ARTIGO

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