Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2)

AUTOR(ES)

Wilson, Randall C.

FONTE

International Union of Crystallography

RESUMO

Crystal structures of the ubiquitin-conjugating enzyme E2-25K M172A mutant protein at pH 6.5 and pH 8.5 were determined to 1.9 and 2.2 Å resolution, respectively. Examination of the structures revealed domain–domain interactions between the UBC and UBA domains which have not previously been reported.

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