Structural Assessment of Chemical Constituent of Sidaguri (Sida rhombifolia Linn) and Its Ability to Inhibit Cyclooxygenase
AUTOR(ES)
Tanumihadja, Maria
FONTE
Pesqui. Bras. Odontopediatria Clín. Integr.
DATA DE PUBLICAÇÃO
31/10/2019
RESUMO
Abstract Objective: To elicit the structure of isolated compounds from roots of sidaguri (Sida rhombifolia Linn). Material and Methods: Several organic standard protocols were involved, including extraction, fractionation, and phytochemical testing. Further spectroscopy methods, FTIR and 1HNMR, were used to determine the predicted structure of molecules, while their ability to inhibit cyclooxygenase (COX 1 and 2) were tested using in vitro method. Results: Overall assessments showed that the structure of the sidaguri is a long chain aliphatic carboxylic acid and identified as Z-3, 6, 6 trimethylhept-2-en-1-ol (T12) and nonanoic (T13). Both isolates significantly inhibit COX-1 and COX-2 non-selectively (the COX-1/COX-2 ratio for T12 was 0.91 and 0.82; while COX-1/COX-2 ratio for T13 was 0.89 and 0.87 at concentrations of 0.05 and 0.025 µg/mL respectively). Conclusion: The active compounds of Sidaguri have anti-inflammatory effect by inhibiting COX non-selectively.
Documentos Relacionados
- Emergência e desenvolvimento de guanxuma (Sida rhombifolia), capim-braquiária (Brachiaria decumbens) e cana-de-açúcar (Saccharum spp.) influenciados por subprodutos da destilação do álcool
- Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia
- Crescimento e nutrição mineral de Sida rhombifolia
- Novas substâncias para Malvaceas: Sida rhombifolia L.
- NOVAS SUBSTÂNCIAS PARA MALVACEAS: Sida rhombifolia L.