STK Receptor Tyrosine Kinase Regulates Susceptibility to Infection with Listeria monocytogenes

AUTOR(ES)

Lutz, Michael A.

FONTE

American Society for Microbiology

RESUMO

We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria.

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