Stimulus Generalization of Conditioned Eyelid Responses Produced Without Cerebellar Cortex: Implications for Plasticity in the Cerebellar Nuclei
AUTOR(ES)
Ohyama, Tatsuya
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
In Pavlovian eyelid conditioningand adaptation of the vestibulo-ocular reflex, cerebellar cortex lesions fail to completely abolish previously acquired learning, indicating an additional site of plasticity in the deep cerebellar or vestibular nucleus. Three forms of plasticity are known to occur in the deep cerebellar nuclei: formation of new synapses, plasticity at existingsynapses, and changes in intrinsic excitability. Only a cell-wide increase in excitability predicts that learningshould generalize broadly from a trainingstimulus to other stimuli capable of supporting learning, whereas the alternatives predict that learning should be relatively specific to the trainingstimulus. Here we show that deep nucleus plasticity, as assessed by conditioned eyelid responses produced without input from the cerebellar cortex, is relatively specific to the trainingconditioned stimulus (CS). We trained rabbits to a tone or light CS with periorbital stimulation as the unconditioned stimulus (US), and pharmacologically disconnected the cerebellar cortex duringa posttraininggeneralization test. The short-latency conditioned responses unmasked by this treatment showed strongdecrement alongthe dimension of auditory frequency and did not generalize across stimulus modalities. These results cannot be explained solely by a cell-wide increase in the excitability of deep nucleus neurons, and imply that an input-specific mechanism in the deep cerebellar nucleus operates as well.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=218000Documentos Relacionados
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