Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

Cavalcante, José Marcílio Sobral, Nogueira, Tiago Bezerra de Sá de Souza, Tomaz, Anna Cláudia de Andrade, Antas e Silva, Davi, Agra, Maria de Fátima, Souza, Maria de Fátima Vanderlei de, Carvalho, Paulo Roberto Cavalcanti, Ramos, Sílvia Rafaelli, Nascimento, Silene Carneiro do, Gonçalves-Silva, Teresinha

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

AUTOR(ES)

Cavalcante, José Marcílio Sobral, Nogueira, Tiago Bezerra de Sá de Souza, Tomaz, Anna Cláudia de Andrade, Antas e Silva, Davi, Agra, Maria de Fátima, Souza, Maria de Fátima Vanderlei de, Carvalho, Paulo Roberto Cavalcanti, Ramos, Sílvia Rafaelli, Nascimento, Silene Carneiro do, Gonçalves-Silva, Teresinha

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2010

RESUMO

Sidastrum paniculatum (L.) Fryxell belongs to the family Malvaceae and is popularly known as "malva roxa" or "malvavisco". The phytochemical study of the hexane, CHCl3 and EtOAc phases from the crude ethanol extract of S. paniculatum led to the isolation of six compounds: a mixture of β-sitosterol and stigmasterol, 4-methoxy-3-hydroxybenzoic acid, 4-methoxy-3-hydroxybenzaldehyde, N-trans-feruloyltyramine and kaempferol-3-O-β-D-(6''-E-p -coumaroyl) glucoside. The structural identification of the compounds was made on the basis of spectroscopic methods such as IR, ¹H and 13C NMR with the aid of including two-dimensional techniques, besides comparison with literature data. The β-sitosterol and stigmasterol mixture showed a significant anti-inflammatory activity.