Stem cells from adipose tissue improve the time of wound healing in rats

Ohashi, Camila Melo, Caldeira, Fabio Alves Morikawa, Feitosa-Junior, Denilson José Silva, Valente, André Lopes, Dutra, Paulo Roberto Witter, Miranda, Moysés dos Santos, Santos, Simone do Socorro Damasceno, Brito, Marcus Vinicius Henriques, Ohashi, Otávio Mitio, Yasojima, Edson Yuzur

Stem cells from adipose tissue improve the time of wound healing in rats

AUTOR(ES)

Ohashi, Camila Melo, Caldeira, Fabio Alves Morikawa, Feitosa-Junior, Denilson José Silva, Valente, André Lopes, Dutra, Paulo Roberto Witter, Miranda, Moysés dos Santos, Santos, Simone do Socorro Damasceno, Brito, Marcus Vinicius Henriques, Ohashi, Otávio Mitio, Yasojima, Edson Yuzur

FONTE

Acta Cir. Bras.

DATA DE PUBLICAÇÃO

2016-12

RESUMO

ABSTRACT PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed. RESULTS: All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions. CONCLUSION: Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.