Statistics of Natural Populations. II. Estimating an Allele Probability in Families Descended from Cryptic Mothers
AUTOR(ES)
Arnold, Jonathan
RESUMO
In population studies, adults are frequently difficult or inconvenient to identify for genotype, but a family profile of genotypes can be obtained from an unidentified female crossed with a single unidentified male. The problem is to estimate an allele frequency in the cryptic parental gene pool from the observed family profiles. For example, a worker may wish to estimate inversion frequencies in Drosophila; inversion karyotypes are cryptic in adults but visible in salivary gland squashes from larvae. A simple mixture model, which assumes the Hardy-Weinberg law, Mendelian laws and a single randomly chosen mate per female, provides the vehicle for studying three competing estimators of an allele frequency. A simple, heuristically appealing estimator called the Dobzhansky estimator is compared with the maximum likelihood estimator and a close relative called the grouped profiles estimator. The Dobzhansky estimator is computationally simple, consistent and highly efficient and is recommended in practice over its competitors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1202507Documentos Relacionados
- Effective Size and F-Statistics of Subdivided Populations. II. Dioecious Species
- Genetics of Natural Populations. II. Genic Variation in Populations of Drosophila Pseudoobscura Inhabiting Isolated Mountain Ranges
- A Molecular Approach to the Study of Genic Heterozygosity in Natural Populations. II. Amount of Variation and Degree of Heterozygosity in Natural Populations of DROSOPHILA PSEUDOOBSCURA
- Transposable Elements in Mendelian Populations. II. Distribution of Three COPIA-like Elements in a Natural Population of DROSOPHILA MELANOGASTER
- Combinatorial library diversity: probability assessment of library populations.
