Starvation and refeeding in rats: effect on some parameters of energy metabolism and electrolytes and changes of hepatic tissue
AUTOR(ES)
Namazi, Fatemeh, Omidi, Arash, Abbasi, Sajjad, Afsar, Mina, Honarmand, Masumeh, Nazifi, Saeed
FONTE
Pesq. Vet. Bras.
DATA DE PUBLICAÇÃO
2016-06
RESUMO
Abstract: Regarding the importance of starvation and refeeding and the occurrence of refeeding syndrome in various conditions, the present study was conducted to investigate the effects of refeeding on some parameters of energy metabolism and electrolytes and changes of hepatic tissue in male Wistar rats. Fifty-seven rats were divided into six groups, having 6 to 11 rats. Food was provided ad-libitum until three months and then the first group was considered without starvation (day 0). Other rats were fasted for two weeks. Group 2 was applied to a group immediately after starvation (day 14). Groups 3 to 6 were refed in days 16 till 22, respectively. At the end of each period, blood and tissue samples were taken and histopathological and serum analysis, including serum electrolytes (calcium, phosphorus, sodium, potassium), the energy parameters (glucose, insulin, cortisol) and the liver enzymes (ALT, AST, ALP) were determined. Insulin decreased by starvation and then showed an increasing trend compared to starvation period, which the highest amount of this parameter was observed eight days post-refeeding. Serum glucose level showed the opposite pattern of insulin. Histopathological examination of the tissue sections revealed clear vacuoles after starvation and refeeding, in which the severity of lesions gradually decreased during refeeding. The cortisol level decreased by starvation and then increased during refeeding. Also, potassium and phosphorus concentrations declined by refeeding and the serum sodium and potassium levels were changed in the relatively opposite manner. The calcium level decreased by starvation and then increased during refeeding. These results could help recognize and remedy the refeeding syndrome.
Documentos Relacionados
- ADMINISTRATION OF H2 BLOCKERS IN NSAID INDUCED GASTROPATHY IN RATS: effect on histopathological changes in gastric, hepatic and renal tissues
- Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats.
- The effect of starvation and refeeding on cell population kinetics in the rat small bowel mucosa.
- Electrolytes, fluids and energy metabolism in traumatic brain oedema.
- The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats