Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry
AUTOR(ES)
Barbosa, Samantha S., Leal, Felipe D., Padilha, Monica C., Silva, Raphael S. F., Pereira, Henrique Marcelo G., Aquino Neto, Francisco R., Silva Júnior, Ademário I. da
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry was used for the identification of forty doping agents. The improvement in the specificity was remarkable, allowing the resolution of analytes that could not be done by one-dimensional chromatographic systems. The sensitivity observed for different classes of prohibited substances was clearly below the value required by the World Anti-Doping Agency. In addition time-of-flight mass spectrometry gives full spectrum for all analytes without any interference from the matrix, resulting in selectivity improvements. These results could support the implementation of an exhaustive monitoring approach for hundreds of doping agents in a single injection.
Documentos Relacionados
- Comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry: new biomarker parameter proposition for the characterization of biodegraded oil
- Comprehensive two-dimensional gas chromatography with time of flight mass spectrometry applied to analysis of Fischer-Tropsch synthesis products obtained with and without carbon dioxide addition to feed gas
- Quantitative Analysis of Endocrine Disruptors by Comprehensive Two-Dimensional Gas Chromatography
- Preliminary Investigation of Medicinal Herb Adulteration Using Comprehensive Two-Dimensional Gas Chromatography and Chemometric Analysis
- Profiling of Arabidopsis Secondary Metabolites by Capillary Liquid Chromatography Coupled to Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry1