Specific tolerance across a discordant xenogeneic transplantation barrier.

AUTOR(ES)

Lee, L A

RESUMO

Successful induction of tolerance across disparate (discordant) species barriers could overcome the organ shortage that presently limits clinical transplantation. We demonstrate here that xenogeneic swine thymic transplants can induce tolerance to swine antigens in mice, while positively selecting functional host CD4+ T cells. Immunologically normal C57BL/10 mice were thymectomized and depleted of T and natural killer cells; then they received transplants of fetal pig thymus and liver fragments. Mature mouse CD4+ T cells developed in the pig thymus grafts and migrated to the periphery. Swine grafts grew markedly and no anti-pig IgG response was produced. Mixed lymphocyte reactions confirmed that the new T cells were functional and were tolerant to pig antigens.

Documentos Relacionados

• Increased bile duct complications in liver transplantation across the ABO barrier.
• Osmotic flows across the blood-joint barrier.
• Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.
• Heterologous immunity provides a potent barrier to transplantation tolerance
• Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation.