Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats.
AUTOR(ES)
Huggins, C B
RESUMO
The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythro-leukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=346907Documentos Relacionados
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