Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
AUTOR(ES)
Cai, Lin; Hou, Wen
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2020-05
RESUMO
In this study, we successfully demonstrated a strategy for specific disulfide bond formation by hybridization of two complementary peptide nucleic acid strands. Peptides were linked to the pair of complementary peptide nucleic acids by native chemical ligation, respectively, and base pairing drove the two peptides into close proximity for interchain disulfide bond formation. Since peptide nucleic acids directed system is easier to manipulate than deoxyribonucleic acid system, this system will be more useful and have a broader application scope in the construction of complex biomolecular structures.
Documentos Relacionados
- Information transfer from DNA to peptide nucleic acids by template-directed syntheses.
- Information transfer from peptide nucleic acids to RNA by template-directed syntheses.
- Complete pathway for protein disulfide bond formation encoded by poxviruses
- Disulfide bond formation in the eye lens.
- Inhibition of a DNA-helicase by peptide nucleic acids.
